Peroxiredoxin 5 Protein, Mouse, Recombinant (His Tag)

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Peroxiredoxin 5 Protein, Mouse, Recombinant (His Tag): Product Information

Purity
> 92 % as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Activity
Measured by its ability to reduce H2O2.
The specific activity is > 100 pmoles/min/μg.
Protein Construction
A DNA sequence encoding the mouse PRDX5 (mitochondrial) (P99029-1) (Met 49-Leu 210) was expressed, with a polyhistide tag at the N-terminus.
Accession#
Expressed Host
E. coli
Species
Mouse
Predicted N Terminal
Met
Molecule Mass
The recombinant mouse PRDX5 consisting of 173 amino acids and migrates as an approximately 18.5 kDa band in SDS-PAGE under reducing conditions as predicted.
Formulation
Lyophilized from sterile PBS, pH 7.5
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Peroxiredoxin 5 Protein, Mouse, Recombinant (His Tag): Images

Peroxiredoxin 5 Protein, Mouse, Recombinant (His Tag): Alternative Names

AOEB166 Protein, Mouse; AOPP Protein, Mouse; Pmp20 Protein, Mouse; Prdx6 Protein, Mouse; PrxV Protein, Mouse

Peroxiredoxin 5 Background Information

Peroxiredoxin-5, also known as Alu corepressor 1, Antioxidant enzyme B166, Liver tissue 2D-page spot 71B, Peroxisomal antioxidant enzyme, Thioredoxin peroxidase PMP2, Thioredoxin reductase, PRDX5 and ACR1, is cytoplasm protein which belongs to the?peroxiredoxin 2 family. Peroxiredoxin-5 / PRDX5 reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Peroxiredoxin-5 / PRDX5 is involved in intracellular redox signaling. The Peroxiredoxins / Prx are a family of 25 kDa peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups ( PRDX1,PRDX2, PRDX3, PRDX4, PRDX5, PRDX6 ) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.
Full Name
peroxiredoxin 5
References
  • Seo M.S., et al., 2000, J. Biol. Chem. 275: 20346-54.
  • Declercq J.-P., et al., 2001, J. Mol. Biol. 311:751-9.
  • Noh,D.Y. et al., 2001, Anticancer Res. 21 (3B): 2085-90.
  • Schremmer,B. et al., 2007, Subcell Biochem. 44 :317-44.
  • Differences in Proinflammatory Property of Six Subtypes of Peroxiredoxins and Anti-Inflammatory Effect of Ligustilide in Macrophages
    Author
    Zhao, LX;Du, JR;Zhou, HJ;Liu, DL;Gu, MX;Long, FY;
    Year
    2016
    Journal
    PLoS ONE
    Application
    cell-based
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