Anti-NRG1 Beta 1 Antibody

1/1
Price:
Size:
Number:

Anti-NRG1 Beta 1 Antibody (Mouse Monoclonal antibody) General Information

Product name
Anti-NRG1 Beta 1 Antibody
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human Neuregulin-1
No cross-reactivity in WB with
Human NRG1-alpha
Immunogen
A synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1.
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, a synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2b Clone #03
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-NRG1 Beta 1 Antibody (Mouse Monoclonal antibody) Validated Applications

Application Dilution
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-NRG1 Beta 1 Antibody (Mouse Monoclonal antibody) Images

Anti-NRG1-beta 1 mouse monoclonal antibody at 1:500

Lane A: Human NRG1-beta1 (11609-H01H2) (100ng)

Lane B: Human NRG1-alpha (13499-H02H) (100ng)

Secondary

Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution.

Performed under reducing conditions.

Anti-NRG1 Beta 1 Antibody: Alternative Names

Anti-ARIA Antibody; Anti-GGF Antibody; Anti-GGF2 Antibody; Anti-HGL Antibody; Anti-HRG Antibody; Anti-HRG1 Antibody; Anti-HRGA Antibody; Anti-MST131 Antibody; Anti-MSTP131 Antibody; Anti-NDF Antibody; Anti-Neuregulin 1 Antibody; Anti-NRG1-IT2 Antibody; Anti-SMDF Antibody

Neuregulin-1 Background Information

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
Full Name
neuregulin 1
References
  • Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
  • Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
  • Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
Add to Cart Successfully Add to Cart Failed Shopping cart is being updated, please wait