NGF Function

The Vital NGF Function

NGF function has long been recognized as a crucial function in development and maintenance of the peripheral nervous system. Without NGF, these neurons undergo apoptosis. Promoting axonal growth is also one of NGF function. Studies have shown that it causes axonal branching and a bit of elongation. NGF binds with at least two classes of receptors: the p75 and TrkA. NGF binds to high-affinity tyrosine kinase receptor TrkA. TrkA dimerizes and autophosphorylates its tyrosine kinase segment, which leads to the activation of PI 3-kinase, ras, and PLC signaling pathways. Alternatively, the p75 receptor can form a heterodimer with TrkA which has higher affinity and specificity for NGF.

NGF Function for Clinical Significance

One of NGF function for Clinical significance is that NGF prevents or reduces neuronal degeneration in animal models of neurodegenerative diseases and these encouraging results in animals have led to several clinical trials in humans. NGF function has also been shown to promote peripheral nerve regeneration in rats. The expression of NGF is increased in inflammatory diseases where it suppresses inflammation. NGF function has also appeared to promote myelin repair. Hence NGF may be useful for the treatment of multiple sclerosis. NGF could also be involved in various psychiatric disorders, such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Dysregulation of NGF signaling has also been linked to Alzheimer's disease.

23000+ Products
cDNA Clones
Recombinant Cytokines
Neurotrophin & Receptor
NGF Related Information +
- NGF molecular weight
- NGF structure
- NGF function
- NGF signaling / pathway
- NGF receptor
-- NGF TrkA
-- NGFR / p75
BDNF Related Information +
- BDNF Gene
- BDNF function
- BDNF signaling / pathway
- BDNF receptor
-- BDNF TrkB
-- NGFR / p75
• Other Neurotrophin & Receptor+
- Neurotrophin-3 / NT-3
- TrkA / NTRK1
- TrkB / NTRK2
- TrkC / NTRK3
- NGFR (p75 / p75 NTR)
GDNF Family
GDNF (Glial cell line-derived neurotrophin)
Other Neurotrophic Factors & Receptors
Gp130 / IL6ST
LIFR / CD118
CNTF / Ciliary Neurotrophic Factor
NRG1 / Neuregulin 1
NRG4 / Neuregulin 4
Pleiotrophin / PTN
Growth Factor Family
Ephrin & Eph Receptor
EGF & Receptor
FGF & Receptor
Insulin-like Growth Factor System
Neurotrophin & Receptor
PDGF & Receptor
Receptor Tyrosine Kinase
R-Spondin Protein
VEGF & Receptor
Wnt Ligands & Receptors