M-CSF: M-CSF Protein | M-CSF Antibody

M-CSF Background

Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

Reference for M-CSF

  • Pandit J. et al., 1992, Science. 258: 1358-62.
  • Tokai M. et al., 2000, J Bacteriol. 182(10): 2865-8.
  • Fan X. et al., 2001, Am J Physiol Endocrinol Metab. 280(1): E103-11.
  • Frangogiannis NG. et al., 2003, Am J Physiol Heart Circ Physiol. 285 (2): H483-92.
  • Cupp JS. et al., 2007,Am J Surg Pathol. 31(6): 970-6.

M-CSF Protein

M-CSF protein function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.

M-CSF protein sequence

This sequence information is just for reference only.From Uniport

  • Length
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M-CSF Antibody

There are 13 M-CSF antibodies which are validated in multiple tissues with various applications, including FCM, ELISA, ELISA(Cap), ELISA(Det). There are 1 M-CSF antibody for FCM, 9 M-CSF antibody for ELISA, 2 M-CSF antibody for ELISA(Cap), 1 M-CSF antibody for ELISA(Det). Among all these M-CSF antibodies, there are 2 anti-M-CSF mouse monoclonal antibodies , 6 anti-M-CSF rabbit monoclonal antibodies , 5 anti-M-CSF rabbit polyclonal antibodies . All the M-CSF anbodies are produced in house and all are in stock. M-CSF antibody customerized service is available.

M-CSF Gene

CSF1 gene / cDNA is a protein-coding gene which located on 1p13.3. The CSF1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.197 organisms have orthologs with human gene CSF1.