Anti-Latexin Antibody (FITC)

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Anti-Latexin Antibody (FITC) (Rabbit Monoclonal antibody) General Information

Product name
Anti-Latexin Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Latexin
Immunogen
Recombinant Human Latexin / Lxn protein (Catalog#10211-H07E)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Latexin / Lxn (rh Latexin / Lxn; Catalog#10211-H07E; NP_064554.3; Glu 2-Glu 222) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Rabbit IgG Clone #101
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.1% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-Latexin Antibody (FITC) (Rabbit Monoclonal antibody) Images

Human LXN expression in MCF-7 cells.

Anti-Latexin Antibody (FITC): Alternative Names

Anti-ECI Antibody; Anti-TCI Antibody

Latexin Background Information

Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to theprotease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.
Full Name
latexin
References
  • Liu Q., et al.,(2000), Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. Mol. Biol. Rep. 27:241-246.
  • Gauci S., et al., (2009), Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.nal. Chem. 81:4493-4501.
  • Muzny D.M., et al.,(2006), The DNA sequence, annotation and analysis of human chromosome 3.Nature 440:1194-1198.

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