Text Size:AAA


Insulin-like Growth Factor (IGF) System

Product CategoriesProteinsAntibodiesELISA KitscDNA Clones
Number of Products

胰島素生長因數(IGF)系統 Related Products Index

    胰島素生長因數(IGF)系統 Related Products by Product Type

    胰島素生長因數(IGF)系統 By Species

    胰島素生長因數(IGF)系統 by Signaling Pathways

    胰島素生長因數(IGF)系統 Background

    The insulin-like growth factors (IGFs) are polypeptides with high sequence similarity to insulin. The IGF system (also known as IGF axis consists of two ligands (IGF-1 and IGF-2), two cell-surface receptors (IGF1R and IGF2R), a family of six high-affinity IGF binding proteins (IGFBP 1-6), at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP), as well as a group of enzymes involved in IGFBP degradation. The insulin-like growth factor system plays critical roles in somatic growth in an endocrine fashion (somatomedin hypothesis) as well as proliferation and differentiation of normal and malignant cells in a paracrine/autocrine fashion. Insulin-like growth factor 2 (IGF-2) is thought to be a primary growth factor required for early development while expression of insulin-like growth factor 1 (IGF-1) is required for achieving maximal growth. Insulin-like growth factors act through biding the cell-surface receptors, including IGF1R, IGF2R, the insulin receptor, the insulin-related receptor and possibly other receptors. IGF binding proteins help to modulate IGF action in complex ways that involve both inhibiting IGF action by preventing binding to the IGF-1 receptor as well as promoting IGF action possibly through aiding in delivery to the receptor and increasing IGF half-life. Recent studies have revealed important roles of the insulin-like growth factor system in diseases such as cancer, diabetes and malnutrition.

    胰島素生長因數(IGF)系統 References

    1. Cohen P, et al. (1991) Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells. Journal of Clinical Endocrinology and Metabolism. 73(2): 401-7.
    2. Kawai M, et al. (2008) Insulin-like growth factor-I and bone: lessons from mice and men. Pediatr Nephrol. 24(7): 1277-85.
    3. Lann D, et al. (2008) The role of endocrine insulin-like growth factor-I and insulin in breast cancer. J Mammary Gland Biol Neoplasia. 13(4): 371-9.
    4. Randhawa RS. (2008) The insulin-like growth factor system and fetal growth restrictionn. Pediatr Endocrinol Rev. 6(2): 235-40.