IL5RA: IL5RA Protein | IL5RA Antibody

IL5RA Gene family

IL5RA Background

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA (CD125) is a T-cell-derived cytokine which is particularly important in the development of asthma for the lerminal differentiation, activation and survival of committed cosinophil precursors.

Reference for IL5RA

  • Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.
  • Cheong HS, et al. (2005) Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. J Hum Genet. 50(12): 628-34.
  • Isobe M, et al. (1992) Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. Genomics. 14(3): 755-8.

IL5RA Protein

IL5RA protein function

This is the receptor for interleukin-5. The alpha chain binds to IL5.

IL5RA protein expression

Tissue specificity

Expressed on eosinophils and basophils.

IL5RA protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    420.00
  • Mass (Da)
    47.00

IL5RA Antibody

There are 3 IL5RA antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, WB. There are 1 IL5RA antibody for IHC-P, 1 IL5RA antibody for ELISA, 1 IL5RA antibody for WB. Among all these IL5RA antibodies, there are 3 anti-IL5RA rabbit polyclonal antibodies . All the IL5RA anbodies are produced in house and all are in stock. IL5RA antibody customerized service is available.

IL5RA Gene

IL5RA gene / cDNA is a protein-coding gene which located on 3p26.2. The IL5RA gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog.187 organisms have orthologs with human gene IL5RA.