IL31: IL31 Protein | IL31 Antibody

IL31 Gene family

IL31 Protein

IL31 protein function

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity). {ECO:0000250|UniProtKB:Q6EAL8, ECO:0000269|PubMed:15184896}.

IL31 protein expression

Tissue specificity

Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.

Induction

Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).

IL31 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    164.00
  • Mass (Da)
    18.00

IL31 Antibody

There are 4 IL31 antibodies which are validated in multiple tissues with various applications, including ELISA. There are 4 IL31 antibody for ELISA. Among all these IL31 antibodies, there are 3 anti-IL31 rabbit polyclonal antibodies , 1 anti-IL31 rabbit monoclonal antibodies . All the IL31 anbodies are produced in house and all are in stock. IL31 antibody customerized service is available.

IL31 Gene

IL31 gene / cDNA is a protein-coding gene which located on 12q24.31. The IL31 gene is conserved in chimpanzee, Rhesus monkey, and dog.77 organisms have orthologs with human gene IL31.