ST2/IL-1 RL1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All ST2/IL-1 RL1 reagents are produced in house and quality controlled, including 10 ST2/IL-1 RL1 Antibody, 2 ST2/IL-1 RL1 ELISA, 28 ST2/IL-1 RL1 Gene, 6 ST2/IL-1 RL1 Lysate, 7 ST2/IL-1 RL1 Protein, 1 ST2/IL-1 RL1 qPCR. All ST2/IL-1 RL1 reagents are ready to use.

More Product Popular With Customers

ST2/IL-1 RL1 Background

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.

ST2/IL-1 RL1 References

  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.