IL1RAPL1 cDNA ORF Clone in Cloning Vector, Mouse

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IL1RAPL1 cDNA ORF Clone in Cloning Vector, Mouse: General Information

Gene
Species
Mouse
NCBI Ref Seq
RefSeq ORF Size
2091 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutation 1782 A/G not causing the amino acid variation.
Description
Full length Clone DNA of Mouse interleukin 1 receptor accessory protein-like 1.
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

IL1RAPL1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

IL1RAPL1 cDNA ORF Clone in Cloning Vector, Mouse: Alternative Names

6330532G10Rik cDNA ORF Clone, Mouse; C030039N24 cDNA ORF Clone, Mouse; IL1R8 cDNA ORF Clone, Mouse; IL1RAPL cDNA ORF Clone, Mouse; MRX34 cDNA ORF Clone, Mouse; OPHN4 cDNA ORF Clone, Mouse; TIGIRR-2 cDNA ORF Clone, Mouse

IL1RAPL1 Background Information

Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 15 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.
Full Name
interleukin 1 receptor accessory protein-like 1
References
  • Frdric Gambino, et al. (2007) IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci. 104 (21): 9063-8.
  • Wheway JM, et al. (2003) A complex deletion-inversion-deletion event results in a chimeric IL1RAPL1-dystrophin transcript and a contiguous gene deletion syndrome. J Med Genet. 40: 127-131.
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