IL1RAPL1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All IL1RAPL1 reagents are produced in house and quality controlled, including 1 IL1RAPL1 Antibody, 25 IL1RAPL1 Gene, 3 IL1RAPL1 Lysate, 3 IL1RAPL1 Protein, 2 IL1RAPL1 qPCR. All IL1RAPL1 reagents are ready to use.

IL1RAPL1 Protein (3)

IL1RAPL1 Antibody (1)

IL1RAPL1 cDNA Clone (25)

NM_014271.3
NM_001160403.1

IL1RAPL1 Lysate (3)

IL1RAPL1 Background

Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a member of interleukin-1 receptor family. The protein structurally comprises three extracellular immunoglobulin domains, which presumably mediate binding of an as yet unidentified ligand, a transmembrane region, and an intracellular domain, which is likely to enable signalling via the NFkB pathway. The means of signalling is almost certain to be identical to that used by the IL1R family and the more distally related Toll protein. L1RAPL1 protein physically interacts via its 15 aa C-terminal domain with neuronal calcium sensor-1 (NCS-1), a protein widely expressed in neurons and the related chromaffin and PC12 cells. IL1RAPL1 is an integral membrane protein responsible for a nonsyndromic form of mental retardation (MR). It is suggested to affect human cognitive ability to some extent, especially the memory and concentration capability.

IL1RAPL1 References

  • Frdric Gambino, et al. (2007) IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci. 104 (21): 9063-8.
  • Wheway JM, et al. (2003) A complex deletion-inversion-deletion event results in a chimeric IL1RAPL1-dystrophin transcript and a contiguous gene deletion syndrome. J Med Genet. 40: 127-131.