Anti-IL-1 beta Antibody

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Anti-IL-1 beta Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-IL-1 beta Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse IL-1 beta
Has cross-reactivity in ELISA with
Human IL1B
Rat IL1B
Canine IL1B
No cross-reactivity in ELISA with
Mouse IL1A
Mouse IL18
Human IL1F7
Human IL1F6
Human IL1F8
Cynomolgus IL1B
Immunogen
Recombinant Mouse IL-1 beta / IL1B protein (Catalog#50101-MNAE)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1 beta / IL1B (rM IL-1 beta / IL1B; Catalog#50101-MNAE; P10749; Val118-Ser269).
Source
Monoclonal Rabbit IgG Clone #001
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL-1 beta Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL-1 beta Antibody: Alternative Names

Anti-Il-1b Antibody; Anti-IL-1beta Antibody

IL-1 beta Background Information

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
Full Name
interleukin 1, beta
References
  • Kim SH, et al. (2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
  • Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
  • Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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