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人 Endoglin / CD105 ELISA Kit

  • Human Endoglin / CD105  ELISA Kit, TYPICAL DATA
  • Human Endoglin / CD105  ELISA Kit, SPECIFICITY
Solid Phase Sandwich ELISA
For the quantitative determination of Human Endoglin / CD105 concentration in serum.
The use of this kit for other sample types need be validated by the end user due to the complexity of natural targets and unpredictable interference.
62.5-4000 pg/mL
The minimum detectable dose of Human Endoglin / CD105 is typically less than 36.27 pg/mL. The MDD was determined by adding three standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
 ENG ELISA Kit Standard Curve
Human Endoglin / CD105  ELISA Kit, TYPICAL DATA
This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
 ENG ELISA Kit Specificity
Human Endoglin / CD105  ELISA Kit, SPECIFICITY
This assay recognizes both recombinant and natural Human CD105. The factors listed below were prepared at 50 ng/mL or 100ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.
Endoglin/CD105  研究背景

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

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貨號: KIT10149-1
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