UMP-CMP kinase / CMPK1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All UMP-CMP kinase / CMPK1 reagents are produced in house and quality controlled, including 3 UMP-CMP kinase / CMPK1 Antibody, 60 UMP-CMP kinase / CMPK1 Gene, 1 UMP-CMP kinase / CMPK1 IP Kit, 1 UMP-CMP kinase / CMPK1 Lysate, 1 UMP-CMP kinase / CMPK1 Protein, 2 UMP-CMP kinase / CMPK1 qPCR. All UMP-CMP kinase / CMPK1 reagents are ready to use.

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UMP-CMP kinase / CMPK1 Background

CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid biosynthesis.

UMP-CMP kinase / CMPK1 References

  • Liou J, et al. (2004) Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium. Molecular Pharmacology. 67(3):806-14.
  • Gerhard DS, et al. (2004) The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Research. 14(10B):2121-7.
  • Segura-Pena D, et al. (2004) Substrate-induced Conformational Changes in Human UMP/CMP Kinase. Journal of Biological Chemistry. 279(32):33882-9.