Anti-Nectin-2 Antibody (PE)

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Anti-Nectin-2 Antibody (PE) (Rabbit Monoclonal antibody) General Information

Product name
Anti-Nectin-2 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Nectin-2
Immunogen
Recombinant Human CD112 / Nectin-2 protein (Catalog#10005-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112 / Nectin-2 (rh CD112 / Nectin-2; Catalog#10005-H08H; NP_002847.1; Met1-Leu360) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #005
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-Nectin-2 Antibody (PE) (Rabbit Monoclonal antibody) Images

Flow cytometric analysis of anti-Human PVRL2(CD112) on A549 cells.

Anti-Nectin-2 Antibody (PE): Alternative Names

Anti-CD112 Antibody; Anti-HVEB Antibody; Anti-Nectin-2 Antibody; Anti-PRR2 Antibody; Anti-PVRR2 Antibody

Nectin-2 Background Information

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
Full Name
poliovirus receptor-related 2 (herpesvirus entry mediator B)
References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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