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MDR1/ABCB1  蛋白

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MDR1/ABCB1 相關信號通路

    MDR1/ABCB1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    MDR1/ABCB1 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    MDR1/ABCB1 概述&蛋白信息

    MDR1/ABCB1 研究背景

    催化活性: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
    亞單位結構: Interacts with PSMB5.
    亞細胞定位: Cell membrane; Multi-pass membrane protein (By similarity).
    組織特異性: Expressed in liver, kidney, small intestine and brain.
    相關疾病 : Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    相似的序列: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
    General information above from UniProt

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