2B4 / CD244 (Protein | Antibody | cDNA Clone | ELISA Kit)

All 2B4 / CD244 reagents are produced in house and quality controlled, including 6 2B4 / CD244 Antibody, 1 2B4 / CD244 ELISA, 13 2B4 / CD244 Gene, 1 2B4 / CD244 IP Kit, 2 2B4 / CD244 Lysate, 2 2B4 / CD244 Protein, 1 2B4 / CD244 qPCR. All 2B4 / CD244 reagents are ready to use.

2B4 / CD244 Protein (2)

2B4 / CD244 Antibody (6)

2B4 / CD244 ELISA Kit & Match Antibody ELISA Pair Set (1)

2B4 / CD244 cDNA Clone (13)

NM_016382.2

2B4 / CD244 qPCR Primer (1)

2B4 / CD244 Lysate (2)

2B4 / CD244 Background

The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.

2B4 / CD244 References

  • Nakajima H, et al. (2000) 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 61(1): 39-43.
  • Chuang SS, et al. (2001) 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol. 167(11): 6210-6.
  • McNerney ME, et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 42(4): 489-94.
  • Mathew SO, et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 39(6): 1632-41.