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VISTA / B7-H5 / GI24 Immune Checkpoint Pathway

VISTA / B7-H5 / GI24 Immune Checkpoint Pathway: Description

A novel negative checkpoint regulator designated V-domain Ig Suppressor of T cell Activation (VISTA) is a newly identified Ig domain-containing immune-checkpoint molecule that directly suppresses T-cell activation in vitro and in vivo. The human and murine VISTA / B7-H5 / GI24 proteins share 90% identity and display similar expression patterns. VISTA / B7-H5 / GI24 is constitutively expressed within the hematopoietic compartment, with the highest expression level on myeloid cells and a lower level on CD4+, CD8+ T cells, and Foxp3+CD4+ regulatory T cells. A soluble VISTA-Ig protein that contains the extracellular domain fused with Ig-crystalizable fragment (Fc) or full-length VISTA / B7-H5 / GI24 expressed on APCs acts as a ligand to suppress T-cell proliferation and cytokine production. In addition, VISTA / B7-H5 / GI24 might function as an inhibitory receptor on T cells to suppress their activation . VISTA / B7-H5 / GI24-specific monoclonal antibody (mAb) enhances disease severity in the experimental autoimmune encephalomyelitis (EAE) model, as well as boosts antitumor immunity in multiple murine tumor models.

VISTA / B7-H5 / GI24 Immune Checkpoint Pathway: Reference

Kathleen M. Mahoney et al. Combination cancer immunotherapy and new immunomodulatory targets. Nature Reviews Drug Discovery 2015;14:561–584.

VISTA / B7-H5 / GI24 Immune Checkpoint Pathway: Relatives

Co-inhibitory immune checkpoint pathways Co-stimulatory immune checkpoint pathways
PD1 & PD-L1 immune checkpoint pathway CD40 & CD40L immune checkpoint pathway
CTLA-4 & CD80 (CD86) immune checkpoint pathway OX40 & OX40L immune checkpoint pathway
B7-H3 / CD276 immune checkpoint pathway HVEM & LIGHT immune checkpoint pathway
B7-H4 / B7S1 / B7x immune checkpoint pathway CD28 & CD80 (CD86) immune checkpoint pathway
HVEM & BTLA immune checkpoint pathway GITR & GITR Ligand immune checkpoint pathway
HVEM & CD160 immune checkpoint pathway CD27 & CD70 immune checkpoint pathway
LAG3 / CD223 / Lymphocyte activation gene 3 immune checkpoint pathway 4-1BB & 4-1BBL immune checkpoint pathway
Galectin-9 & TIM-3 immune checkpoint pathway ICOS & ICOS Ligand immune checkpoint pathway
Indoleamine 2,3-dioxygenase/IDO immune checkpoint pathway CD266 & CD155 immune checkpoint pathway
CEACAM1 / CD66a immune checkpoint pathway  
SIRP alpha & CD47 immune checkpoint pathway  
2B4 & CD48 immune checkpoint pathway  
TIGIT & CD155 immune checkpoint pathway  
請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”