DR4 / TRAIL R1: DR4 / TRAIL R1 Protein | DR4 / TRAIL R1 Antibody

DR4 / TRAIL R1 Gene family

DR4 / TRAIL R1 Background

Tumor necrosis factor receptor superfamily, member 1a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF1/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF1A serves as a receptor for the cytotoxic ligand TNFSF1/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF1A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.

Reference for DR4 / TRAIL R1

  • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
  • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.

DR4 / TRAIL R1 Protein

DR4 / TRAIL R1 protein function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. {ECO:0000269|PubMed:26457518, ECO:0000269|PubMed:9430227}.

DR4 / TRAIL R1 protein expression

Tissue specificity

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

DR4 / TRAIL R1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    468.00
  • Mass (Da)
    50.00

DR4 / TRAIL R1 Antibody

There are 9 DR4 / TRAIL R1 antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), FCM, ELISA, ELISA(Det). There are 1 DR4 / TRAIL R1 antibody for ELISA(Cap), 4 DR4 / TRAIL R1 antibody for FCM, 5 DR4 / TRAIL R1 antibody for ELISA, 1 DR4 / TRAIL R1 antibody for ELISA(Det). Among all these DR4 / TRAIL R1 antibodies, there are 4 anti-DR4 / TRAIL R1 mouse monoclonal antibodies , 2 anti-DR4 / TRAIL R1 rabbit monoclonal antibodies , 3 anti-DR4 / TRAIL R1 rabbit polyclonal antibodies . All the DR4 / TRAIL R1 anbodies are produced in house and all are in stock. DR4 / TRAIL R1 antibody customerized service is available.

DR4 / TRAIL R1 Gene

TNFRSF10A gene / cDNA is a protein-coding gene which located on 8p21.3. The TNFRSF10A gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat.31 organisms have orthologs with human gene TNFRSF10A.