Targeted Therapy: Targets

Targeted Therapy: Targets Collection

2B4 adenosine A2a receptor Akt ALK AR Aurora A
Aurora B Aurora C B7-H3 B7-H4 Bcl-2 Bcr-Abl
B-Raf BTK BTLA CA-125 CAIX CCR4
CD137 CD137L CD155 CD160 CD19 CD20
CD25 CD27 CD28 CD30 CD33 CD40
CD40L CD47 CD48 CD52 CD70 CD80
CD86 CDK4 CDK6 CEA CEACAM1 ChK1
ChK2 c-KIT c-Met/HGFR COX2 CTLA-4 DNAM-1
DR5 EGFR EpCAM EPHA3 ERK1 ERK2/p38 MAPK
FAP FGFR1 FGFR2 FGFR3 FGFR4 FGFR5
FGFR6 Flt-3 Galectin-9 GITR GITRL gpA33
HDAC1 HDAC2 HER2 HER3 HER4/ERBB4 HGF
HVEM ICOS ICOS Ligand IDO IGF1R KRAS
LAG3 LIGHT MDM2 MEK1 MEK2 MET
mTOR Mucins NTRK1 NTRK2 NTRK3 OX40
OX40L p53 PARP1 PARP2 PD-1 PDGFR-α
PDGFR-β PD-L1 PD-L2 PI3Kα PI3Kβ PI3Kγ
PI3Kδ PSMA RAF-1 RANKL RET ROS1
SIRP alpha Smothened Syk TIGIT TIM-3 TRAIL
TRAILR1 VEGF VEGFR-1 VEGFR-2 VEGFR-3 VISTA

Targeted Therapy: Targets-EGFR

The EGFR, also known as ErbB1, is a 170 kDa protein belonging to the four-member ErbB family of transmembrane tyrosine kinase growth factor receptors. Binding by a number of ligands induces conformational alterations in the single chain receptor, allowing dimerization or oligomerization with other EGFR molecules or other members of the ErbB family. Multimer formation leads to asymmetric autophosphorylation of a tyrosine residue on the intracellular portion of one of the molecules, allowing the receptor to recruit docking proteins and signal transduction molecules. The resulting cascades, involving the Ras/mitogen-activating protein (MAP) kinase pathway, the Phosphoinositide-3 kinase (PI3K)/Akt pathway, Src family kinases, and signal transducers and activator of transcription (STAT) proteins, result in upregulation of mitogenic, antiapoptotic, angiogenic, and pro-invasive cellular mechanisms. EGFR is expressed or overexpressed in many cancers, Which make it a useful target for targeted therapies of cancers, such as breast cancer, colorectal cancer, head and neck cancer, non-small-cell lung cancer, ovivian cancer and pancreatic cancer.

Targeted Therapy: Targets-VEGF

Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF RTK signaling. Currently, several VEGF inhibitors are undergoing clinical testing in several malignancies. VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration.

Targeted Therapy
What is Targeted Therapy
Targeted Therapy: Targets
Targeted Therapy for Cancer
Targeted Therapy for Kidney Cancer
Targeted Therapy for Liver Cancer
Colorectal Cancer Targeted Therapy
What is Targeted Therapy for Cancer
Targeted Therapy for Leukemia
Targeted Therapy for Pancreatic Cancer
Prostate Cancer Targeted Therapy
Targeted Therapy for Ovarian Cancer
Melanoma Targeted Therapy
Targeted Therapy for Lung Cancer
Targeted Therapy for Breast Cancer
EGFR Targeted Therapy
EGFR Targeted Therapy for Breast Cancer
EGFR Targeted Therapy for Colorectal Cancer
EGFR Targeted Therapy for Head and Neck Cancer
EGFR Targeted Therapy for Non-Small-Cell Lung Cancer
EGFR Targeted Therapy for Ovarian Cancer
EGFR Targeted Therapy for Pancreatic Cancer
HER2 Targeted Therapy
HER2 Targeted Therapy for Breast Cancer
HER2 Targeted Therapy for Colorectal Cancer
Her2 targeted therapy for Ovarian cancer
VEGF Targeted Therapy
VEGF Targeted Therapy for Breast Cancer
VEGF Targeted Therapy for Lung Cancer
VEGF Targeted Therapy for Prostate Cancer
VEGF Targeted Therapy for Colorectal Cancer
BRAF Targeted Therapy
BRAF Targeted Therapy for Melanoma
BRAF Targeted Therapy for Lung Cancer
ALK Targeted Therapy
ALK Targeted Therapy for Lung Cancer
ALK Targeted Therapy for Anaplastic Large Cell Lymphoma
Immune Checkpoint Targeted Therapy
Targeted Therapy Drugs
Targeted Therapy Drugs: Elotuzumab
Targeted Therapy Drugs: Necitumumab
Targeted Therapy Drugs: Daratumumab
Targeted Therapy Drugs: Ramucirumab
Targeted Therapy Drugs: Trastuzumab
Targeted Therapy Drugs: Vemurafenib
Targeted Therapy Drugs: Crizotinib
The Differences between Chemotherapy and Targeted Therapy
Side Effects of Targeted Therapy
Oral Targeted Therapy
Targeted Therapy Resistance
How does Targeted Therapy Work