Targeted Therapy for Lung Cancer

Targeted Therapy for Lung Cancer: Introduction

Lung cancer is the leading cause of cancer related mortality in the United States, with an estimated 224,390 new cases and 158,080 deaths anticipated in 2016 (ACS 2016​). Classically, treatment decisions have been empiric and based upon histology of the tumor. Platinum based chemotherapy remains the cornerstone of treatment. However, survival rates remain low. Novel therapies and treatment strategies are needed.
Lung cancer is comprised of two main histologic subtypes: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Over the past decade, it has become evident that subsets of NSCLC can be further defined at the molecular level by recurrent 'driver' mutations that occur in multiple oncogenes, and targeted therapy has been developped for lung cancer, which show merits compared with chemotherapy.

Non-Small Cell Lung Cancer (NSCLC) Targeted Therapy

Driver mutations happened in most of non-small cell lung cancer (NSCLC). These mutations in receptors or protein kinases can stimulate a complex cascade of cross signalling pathways such as the RAS-RAF-MEK-ERK or MAPK, PI3K-AKT-mTOR or JAK-STAT pathways, resulting uncontrolled cellular growth, proliferation and survival. Successful targeted therapy involves the identification and inhibition of these dysregulated pathways by either small molecule inhibitors or receptor monoclonal antibodies (mAb).

Small Cell Lung Cancer Targeted Therapy

Small cell lung cancer (SCLC) accounts for 15% of lung cancer cases and is associated with a dismal prognosis. Standard therapeutic regimens have been improved over the past decades, but without a major impact on patient survival. The development of targeted therapies based on a better understanding of the molecular basis of the disease is urgently needed.

EGFR Targeted Therapy Lung Cancer

Small cell lung cancer (SCLC) accounts for 15% of lung cancer cases and is associated with a dismal prognosis. Standard therapeutic regimens have been improved over the past decades, but without a major impact on patient survival. The development of targeted therapies based on a better understanding of the molecular basis of the disease is urgently needed.

Targeted Therapy
What is Targeted Therapy
Targeted Therapy: Targets
Targeted Therapy for Cancer
Targeted Therapy for Kidney Cancer
Targeted Therapy for Liver Cancer
Colorectal Cancer Targeted Therapy
What is Targeted Therapy for Cancer
Targeted Therapy for Leukemia+
- Targeted Therapy for Acute Lymphocytic Leukemia
- Targeted Therapy for Chronic Lymphocytic Leukemia
- Targeted Therapy for Chronic Myeloid Leukemia
- Targeted Therapy for Acute Myeloid Leukemia
Targeted Therapy for Pancreatic Cancer
Prostate Cancer Targeted Therapy
Targeted Therapy for Ovarian Cancer
Melanoma Targeted Therapy
Targeted Therapy for Lung Cancer+
- Non-Small Cell Lung Cancer (NSCLC) Targeted Therapy
- Small Cell Lung Cancer Targeted Therapy
- EGFR Targeted Therapy Lung Cancer
Targeted Therapy for Breast Cancer+
- Targeted Therapy for Hormone Receptor Positive Breast Cancer
- Targeted Therapy for HER2 Positive Breast Cancer
- Targeted Therapy for Triple-Negative Breast Cancer
- What is Targeted Therapy for Breast Cancer
EGFR Targeted Therapy
HER2 Targeted Therapy
VEGF Targeted Therapy
BRAF Targeted Therapy
ALK Targeted Therapy
Immune Checkpoint Targeted Therapy
Targeted Therapy Drugs
The Differences between Chemotherapy and Targeted Therapy
Side Effects of Targeted Therapy
Oral Targeted Therapy
Targeted Therapy Resistance
How does Targeted Therapy Work