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ROR2  Protein, Antibody, ELISA Kit, cDNA Clone

ROR2 相关研究领域

ROR2 相關信號通路

    ROR2 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    ROR2 概述&蛋白信息

    ROR2 研究背景

    催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
    亞單位結構: Homodimer; promotes osteogenesis. Binds YWHAB. Interacts with WTIP (By similarity). {ECO:0000250}.
    亞細胞定位: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
    發育階段: Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
    相關疾病 : DISEASE: Brachydactyly B1 (BDB1) [MIM:113000]: A form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type B1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Symphalangism is also a feature. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Robinow syndrome autosomal recessive (RRS) [MIM:268310]: A recessive form of Robinow syndrome, a disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally far more severe in recessive cases, particularly skeletal abnormalities. All patients with the recessive form suffer from vertebral segmentation abnormalities, resulting in scoliosis and chest deformities. Rib fusions are considered to be characteristic of the autosomal recessive form. Patients can also present brachydactyly, with extensive aplasia/hypoplasia of the phalanges and metacarpals/metatarsals, and brachy-syn-polydactyly of the hands and oligodactyly of the feet. {ECO:0000269|PubMed:10932186, ECO:0000269|PubMed:10932187}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE-ProRule:PRU00090}.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.; Contains 1 kringle domain. {ECO:0000255|PROSITE-ProRule:PRU00121}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    ROR2 別稱

    BDB,BDB1,NTRKR2, [homo-sapiens]
    mRor2,Ntrkr2, [mus-musculus]

    ROR2 相關文獻

    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”