VEGFR3/FLT4 Protein

VEGFR3/FLT4 Protein Overview

VEGFR3/FLT4 protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

VEGFR3/FLT4 protein name

Recommended name
Vascular endothelial growth factor receptor 3
Short name
VEGFR-3||FLT-4
Aliases
PCL, VEGFR3
Alternative name
Fms-like tyrosine kinase 4 Tyrosine-protein kinase receptor FLT4

VEGFR3/FLT4 Gene family protein

VEGFR3/FLT4 Protein Sequence

Species Human VEGFR3/FLT4 protein
Length 1363
Mass (Da) 152757
Sequence Human VEGFR3/FLT4 protein sequence
Species Mouse VEGFR3/FLT4 protein
Length 1363
Mass (Da) 153016
Sequence Mouse VEGFR3/FLT4 protein sequence
Species Rat VEGFR3/FLT4 protein
Length 1363
Mass (Da) 153317
Sequence Rat VEGFR3/FLT4 protein sequence

VEGFR3/FLT4 Protein Molecular Weight & PI

Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 25-1363 Vascular endothelial growth factor

Molecular weight (Da)

150216.22

Theoretical pI

5.87

VEGFR3/FLT4 Protein Structure

Crystal structure of VEGFR-3 extracellular domains D4-5
Deposited
2013-06-10   Released:  2013-07-31
Deposition Author(s)
Leppanen, V.-M., Tvorogov, D., Kisko, K., Prota, A.E., Jeltsch, M., Anisimov, A., Markovic-Mueller, S., Stuttfeld, E., Goldie, K.N., Ballmer-Hofer, K., Alitalo, K.
Organism(s)
Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.5000 Å
R-Value Free
0.253
R-Value Work
0.210
4BSJ From PDB

Human VEGFR3/FLT4 protein Secondary structure

VEGFR3/FLT4 Protein Interaction

Recombinant VEGFR3/FLT4 Protein Feature

VEGFR3/FLT4 Protein, Human, Recombinant (Fc Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA . 1. Immobilized recombinant human VEGFR3 at 5 μg/ml (100 μl/well) can bind recombinant human VEGF-D at a linear range of 62.5-2000 ng/ml. 2. Immobilized recombinant human VEGF-C at 10 μg/ml (100 μl/well) can bind recombinant human VEGFR3 at a linear range of 0.64-80 ng/ml. 3. Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM.

Recombinant VEGFR3/FLT4 protein citations

Title
CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis
Year
2017
Author
Yan, H;Zhang, C;Wang, Z;Tu, T;Duan, H;Luo, Y;Feng, J;Liu, F;Yan, X;
Journal
Sci Rep
Title
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
Year
2018
Author
Deng, M;Gui, X;Kim, J;Xie, L;Chen, W;Li, Z;He, L;Chen, Y;Chen, H;Luo, W;Lu, Z;Xie, J;Churchill, H;Xu, Y;Zhou, Z;Wu, G;Yu, C;John, S;Hirayasu, K;Nguyen, N;Liu, X;Huang, F;Li, L;Deng, H;Tang, H;Sadek, A;Zhang, L;Huang, T;Zou, Y;Chen, B;Zhu, H;Arase, H;Xia, N;Jiang, Y;Collins, R;You, M;Homsi, J;Unni, N;Lewis, C;Chen, G;Fu, Y;Liao, X;An, Z;Zheng, J;Zhang, N;Zhang, C;
Journal
Nature

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