IL-13 cDNA Clone: Expression and Clone Vector / Plasmid

IL-13 cDNA / Gene Overview

IL13 gene / cDNA is a protein-coding gene which located on 5q31.1. The IL13 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.114 organisms have orthologs with human gene IL13.

IL-13 cDNA / Gene Function

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

IL-13 cDNA / Gene Sequence

LOCUS
LOCUS NM_002188 1282 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens interleukin 13 (IL13), transcript variant 1, mRNA.
ACCESSION
NM_002188
VERSION
NM_002188.2

This sequence information is just for reference only.

IL-13 Family & Reagents

Gene family

IL-13 Gene family reagents (Interleukins)

Approved Symbol Reagent list
IL17B
IL25
IL17F
IL12A
IL36A
IL1A
IL12B
IL3
IL37
IL24
Approved Symbol Reagent list
IL10
IL27
IL36G
IL1F10
IL21
IL1RN
IL5
IL9
IL32
IL15

IL-13 cDNA / Gene Alias

  • allergic rhinitis
  • ALRH
  • BHR1
  • Bronchial hyperresponsiveness-1 (bronchial asthma)
  • IL-13
  • MGC116786
  • MGC116788
  • MGC116789
  • P600

IL-13 cDNA / Gene Expression

Restricted expression toward testis (RPKM 13.9)