DR3 cDNA Clone: Expression and Clone Vector / Plasmid
DR3 cDNA / Gene Overview
TNFRSF25 gene / cDNA is a protein-coding gene which located on 1p36.31. The TNFRSF25 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.156 organisms have orthologs with human gene TNFRSF25.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
DR3 cDNA / Gene Sequence
LOCUS NM_148965 1665 bp mRNA linear PRI 03-JUN-2018
Homo sapiens TNF receptor superfamily member 25 (TNFRSF25), transcript variant 1, mRNA.
This sequence information is just for reference only.
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