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Cathepsin D: Cathepsin D Protein | Cathepsin D Antibody

Cathepsin D Gene family

Cathepsin D Background

Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.

Reference for Cathepsin D

  • Fusek M, et al. (2005) Dual role of cathepsin D: ligand and protease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 149(1): 43-50.
  • Minarowska A, et al. (2007) Regulatory role of cathepsin D in apoptosis. Folia Histochem Cytobiol. 45(3): 159-63.
  • Zaidi N, et al. (2008) Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun. 376(1): 5-9.

Cathepsin D Protein

Cathepsin D protein function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. {ECO:0000269|PubMed:27333034}.

Cathepsin D protein expression

Tissue specificity

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).

Cathepsin D protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    412.00
  • Mass (Da)
    44.00

Cathepsin D Antibody

There are 8 Cathepsin D antibodies which are validated in multiple tissues with various applications, including ELISA, ICC/IF, WB, IHC-P, IP. There are 7 Cathepsin D antibody for ELISA, 1 Cathepsin D antibody for ICC/IF, 5 Cathepsin D antibody for WB, 1 Cathepsin D antibody for IHC-P, 2 Cathepsin D antibody for IP. Among all these Cathepsin D antibodies, there are 4 anti-Cathepsin D rabbit monoclonal antibodies , 4 anti-Cathepsin D rabbit polyclonal antibodies . All the Cathepsin D anbodies are produced in house and all are in stock. Cathepsin D antibody customerized service is available.

Cathepsin D Gene

CTSD gene / cDNA is a protein-coding gene which located on 11p15.5. The CTSD gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, M.oryzae, N.crassa, A.thaliana, rice, and frog.211 organisms have orthologs with human gene CTSD.