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ACVR2A Protein

ACVR2A Protein Overview

ACVR2A reagents

Two types of activin receptors were identified by affinity-crosslinking studies. The type I receptor (ACVR1; 102576) has a molecular weight of 65 kD, while the molecular size of the type II receptor is 85 kD (Mathews and Vale, 1991). Donaldson et al. (1992) cloned cDNAs encoding type II activin receptor of the human. Activin (see 147290) has been suggested to be an autocrine/paracrine regulator in the human placenta. This is supported by the work of Peng et al. (1993), who demonstrated ACVR2 mRNA in human trophoblast cells. They also provided the first evidence of expression of the gene in human brain and ovary. Two different forms of activin receptor type II have been found in mouse and chick (Feijen et al., 1994). Both forms show tissue-specific and temporal-specific differences in the timing of their expression during mouse embryogenesis.

ACVR2A protein family

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

ACVR2A protein name

Recommended name
Activin receptor type-2A
Alternative name
Activin receptor type IIA ACTR-IIA ACTRIIA

ACVR2A Gene family protein

Type 2 receptor serine/threonine kinases

ACVR2A Protein Sequence

Species Human ACVR2A protein
Length 513
Mass (Da) 57848
Sequence Human ACVR2A protein sequence
Species Mouse ACVR2A protein
Length 513
Mass (Da) 57890
Sequence Mouse ACVR2A protein sequence
Species Rat ACVR2A protein
Length 513
Mass (Da) 57893
Sequence Rat ACVR2A protein sequence

ACVR2A Protein Molecular Weight & PI

Activin receptor type-2A precursor (EC (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 20-513 Activin receptor type-2A.

Molecular weight (Da)


Theoretical pI


ACVR2A Protein Structure

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
2010-12-24   Released:  2011-02-09
Deposition Author(s)
Chaikuad, A., Alfano, I., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Krojer, T., Muniz, J.R.C., Raynor, J., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
1.9600 Å
R-Value Free
R-Value Work
3Q4T From PDB

Human ACVR2A protein Secondary structure

ACVR2A Protein Interaction

Recombinant ACVR2A Protein Feature

ACVR2A Protein, Human, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.4-3 µg/mL in the presence of 10 ng/mL recombinant Activin A.

Recombinant ACVR2A protein citations

A validated, sensitive electrophoretic method for the detection of activin receptor type II-Fc fusion proteins in human blood
Martin, L;Zouhiri, N;Audran, M;Marchand, A;
Drug Test Anal
A validated, sensitive electrophoretic method for the detection of activin receptor type II-Fc fusion proteins in human blood
Martin, L;Zouhiri, N;Audran, M;Marchand, A;
Drug Test Anal

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