ACVR2A: ACVR2A Protein | ACVR2A Antibody

ACVR2A Gene family

ACVR2A Background

ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.

Reference for ACVR2A

  • Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  • Chung H, et al. (2008) Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair. PloS one 3(10): e3463.
  • Fitzpatrick E, et al. (2009) Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia. Molecular human reproduction 15(3):195-204.
  • Roten LT, et al. (2009) Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). EJHG. 17(2): 250-7.

ACVR2A Protein

ACVR2A protein function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250|UniProtKB:P27038, ECO:0000269|PubMed:1314589}.

ACVR2A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    513.00
  • Mass (Da)
    57.00

ACVR2A Antibody

There are 3 ACVR2A antibodies which are validated in multiple tissues with various applications, including ELISA, WB, IHC-P. There are 2 ACVR2A antibody for ELISA, 2 ACVR2A antibody for WB, 1 ACVR2A antibody for IHC-P. Among all these ACVR2A antibodies, there are 3 anti-ACVR2A rabbit polyclonal antibodies . All the ACVR2A anbodies are produced in house and all are in stock. ACVR2A antibody customerized service is available.

ACVR2A Gene

ACVR2A gene / cDNA is a protein-coding gene which located on 2q22.3-q23.1. The ACVR2A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.229 organisms have orthologs with human gene ACVR2A.