Recombinant Protein

Sino Biological Inc. has over 10 years' experience of recombinant protein research and development, we have more than 6000 recombinant proteins in stock, covering most hot research areas, such as immune checkpoints, antibody drug targets, CAR-T cell therapy targets, Fc receptors, influenza viral proteins and cytokines.
Possessing high purity and validated bioactivity, Sino Biological recombinant proteins can support your scientific research from biopharmaceutical, protein structure, protein function, cell therapy to tool enzymes.

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Featured Recombinant Proteins

  • Immune Checkpoint proteins
    Immune Checkpoint Proteins

    Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……

  • CAR-T cell therapy targets
    CAR-T Cell Therapy Targets

    Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……

  • Monoclonal Antibody Therapeutic Targets
    Antibody Therapeutic Targets

    Cover most of the hot cancer targets, not only PD-1/PD-L1 and CTLA-4 with approved antibody drugs, but also the ones with prospects, namely TIM-3, CD47, GITR, CEACAM1……

  • Cytokine & Growth Factor
    Cytokine & Growth Factor

    GMP-grade proteins available.
    Cover the whole cytokine family, including interleukin, chemokine and TNFs. Related to biopharmaceutical and cell therapy.

  • Fc Receptors
    Fc Receptors

    Cover most of the Fc receptors with multiple species. Verified high bioactivity of binding to immunoglobulin.
     

  • Biotinylated Protein
    Biotinylated Proteins

    Cover mAb drug targets, CAR-T related targets and vital Fc receptors. The bioactivity of the biotinylated protein is not affected by biotinylaiton.

A Global Leader in Recombinant Protein R & D

Advanced Technology Platforms

  • • Five expression systems to support production
  • • Protein from multiple species to support animal models and drug development
  • • 70 qutomatic bioreactor
  • • 2L-2000L bioreactors to ensure high throughout manufacture
  • • GMP-level workshop
  • • Milligram level protein production

Strict quality control system

  • • Over 1000 methods for activity assay
  • • State-of-the-art analytical equipment set to ensure validated bioactivity
  • • N-terminal amino acid sequence analysis
  • • Better stability to ensure repeated experiments
  • • Qualified raw materials to ensure animal free

Premium Recombinant Protein Products

  • • >85% expressed by eukaryotic cell, close to natural structure
  • • Validated bioactivity
  • • Lower endotoxin: <0.1 EU per μg by LAL
  • • High purity: >95% by SDS-PAGE or HPLC
  • • Carrier Free: dissolved in PBS, without BSA

Recombinant protein of high purity

  • The purity of human TNFα protein (Cat. No. GMP-10602-HNAE) was >97% determined by SEC-HPLC and >96% determined by SDS-PAGE
  • Fig .1 The purity of human TNFα protein (Cat. No. GMP-10602-HNAE) was >97% determined by SEC-HPLC and >96% determined by SDS-PAGE

Recombinant protein with high bioactivity

  • The comparison of VEGF165 bioactivity from Sino Biological (EC50=1.4 ng/ml) and another brand (EC50=4 ng/ml) in cell proliferation assays using HUVEC
  • Fig .2 The comparison of VEGF165 bioactivity from Sino Biological (EC50=1.4 ng/ml) and another brand (EC50=4 ng/ml) in cell proliferation assays using HUVEC.

Recombinant protein with high binding activity

  • The PD-1 (Cat. No. 10377-H03H) binding ability to PD-L2 was measured in a functional ELISA. ED50=0.94 μg/ml
  • Fig .3 The PD-1 (Cat. No. 10377-H03H) binding ability to PD-L2 was measured in a functional ELISA. ED50=0.94 μg/ml.

Custom Recombinant Protein Production

Recombinant Protein Production Service Description
We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.

Sino Biological has in-house capacity to support 1000-2000 recombinant protein development and bulk production per year. We could do rapid protein expression and purification process development and conduct process scaleup studies. We can meet protein production requirements for both high-throughput and large scale bulk productions. In the last couple of years, we have successfully produced over 6000 recombinant protein bulks (in the range of milligram to gram purified proteins). The unprecedented capacity can be utilized by our customers worldwide to accelerate their basic research, structural biology, product discovery, and product development.

We are committed to become the cost-effective centralized lab for recombinant protein and monoclonal antibody bulk production to serve the life science community and biotech industry worldwide. We strive to change the way the life science community and industry generating and sourcing their proteins.

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