Anti-PIGR Antibody

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Anti-PIGR Antibody (Mouse Monoclonal antibody) General Information

Product name
Anti-PIGR Antibody
Validated applications
ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human PIGR
Immunogen
Recombinant Human PIGR Protein (Catalog#10131-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PIGR (rh PIGR; Catalog#10131-H08H; NP_002635.2; Met1-Arg638,365Ser/Gly). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Clone #06
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-PIGR Antibody (Mouse Monoclonal antibody) Validated Applications

Notes
ELISA(Cap): This antibody will detect Human PIGR in ELISA pair set (Catalog: # SEK10131). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10131-MM05).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-PIGR Antibody: Alternative Names

Anti-FLJ22667 Antibody; Anti-MGC125361 Antibody; Anti-MGC125362 Antibody; Anti-PIGR Antibody

PIGR Background Information

Polymeric immunoglobulin receptor, also known asPIGR, is a member of the immunoglobulin superfamilyand aFc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion ofIgAandIgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.
Full Name
polymeric immunoglobulin receptor
References
  • Coyne, R. S. et al., 1995, J. Biol. Chem. 269 (50) :31620-31625. 
  • Kaetzel,C.S., 2001,  Curr Biol. 11(1): R35-38.
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