NOTCH2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All NOTCH2 reagents are produced in house and quality controlled, including 1 NOTCH2 Lysate, 1 NOTCH2 Protein, 1 NOTCH2 qPCR. All NOTCH2 reagents are ready to use.

NOTCH2 Background

Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.