OX40L Protein, Mouse, Recombinant (Fc Tag)

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OX40L Protein, Mouse, Recombinant (Fc Tag): Product Information

Purity
> 90 % as determined by SDS-PAGE.
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mouse Tnfsf4 ( NP_033478.1) (Gln49-Leu198) was expressed with the Fc region of rabbit IgG at the N-terminus..
Accession#
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Ser
Molecule Mass
The recombinant mouse Tnfsf4 consists of 401 amino acids and predicts a molecular mass of 44.4 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

OX40L Protein, Mouse, Recombinant (Fc Tag): Images

OX40L Protein, Mouse, Recombinant (Fc Tag): Alternative Names

Ath-1 Protein, Mouse; Ath1 Protein, Mouse; CD134L Protein, Mouse; gp34 Protein, Mouse; OX-40L Protein, Mouse; Ox40l Protein, Mouse; TXGP1 Protein, Mouse; Txgp1l Protein, Mouse

OX40L Background Information

OX-4L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-4L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-4L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
Full Name
tumor necrosis factor (ligand) superfamily, member 4
References
  • Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
  • Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
  • Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.
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