MMP12 cDNA Clone: Expression and Clone Vector / Plasmid

MMP12 cDNA / Gene Overview

MMP12 gene / cDNA is a protein-coding gene which located on 11q22.2. The MMP12 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.102 organisms have orthologs with human gene MMP12.

MMP12 cDNA / Gene Function

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

MMP12 cDNA / Gene Sequence

LOCUS
LOCUS NM_002426 1881 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens matrix metallopeptidase 12 (MMP12), mRNA.
ACCESSION
NM_002426
VERSION
NM_002426.5

This sequence information is just for reference only.

MMP12 Family & Reagents

MMP12 Gene family reagents (M10 matrix metallopeptidases)

Approved Symbol Reagent list
MMP1
MMP2
MMP3
MMP8
Approved Symbol Reagent list
MMP19
MMP26
MMP7
MMP9

MMP12 cDNA / Gene Alias

  • HME
  • macrophage elastase

MMP12 cDNA / Gene Expression

Biased expression in appendix (RPKM 25.3), urinary bladder (RPKM 15.0) and 7 other tissues