MMP12: MMP12 Protein | MMP12 Antibody

MMP12 Gene family

MMP12 Background

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. Macrophage metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, MMP12, and MMP-12, is a secreted protein which belongs to the peptidase M1A family. MMP12 is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for cleavage of plasminogen to angiotensin, which has an angiostatic effect. It may be involved in tissue injury and remodeling and has significant elastolytic activity. It may be related to prognosis in breast cancer patients. MMP12 promotes fibrosis by limiting the expression of specific ECM-degrading MMPs. Like MMP12, MMP13 expression is highly dependent on IL-13 and type I I-IL-4 receptor signaling. MMP12 is a potent proinflammatory and oncogenic molecule. MMP12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.

Reference for MMP12

  • Shapiro S.D., et al.,(1993), Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J. Biol. Chem. 268:23824-23829.
  • Gronski T.J. Jr., et al., (1997), Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase.J. Biol. Chem. 272:12189-12194.
  • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

MMP12 Protein

MMP12 protein function

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

MMP12 protein expression

Tissue specificity

Found in alveolar macrophages but not in peripheral blood monocytes.

Induction

By exposure to bacterial lipopolysaccharides (LPS). Inhibited by dexamethasone.

MMP12 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    470.00
  • Mass (Da)
    54.00

MMP12 Antibody

There are 1 MMP12 antibodies which are validated in multiple tissues with various applications, including IHC-P, ICC/IF. There are 1 MMP12 antibody for IHC-P, 1 MMP12 antibody for ICC/IF. Among all these MMP12 antibodies, there are 1 anti-MMP12 rabbit polyclonal antibodies . All the MMP12 anbodies are produced in house and all are in stock. MMP12 antibody customerized service is available.

MMP12 Gene

MMP12 gene / cDNA is a protein-coding gene which located on 11q22.2. The MMP12 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.102 organisms have orthologs with human gene MMP12.