Mannan Binding Lectin / MBL2: Mannan Binding Lectin / MBL2 Protein | Mannan Binding Lectin / MBL2 Antibody

Mannan Binding Lectin / MBL2 Gene family

Mannan Binding Lectin / MBL2 Background

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

Reference for Mannan Binding Lectin / MBL2

  • Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
  • Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
  • Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
  • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
  • Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.

Mannan Binding Lectin / MBL2 Protein

Mannan Binding Lectin / MBL2 protein function

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. {ECO:0000269|PubMed:14515269}.

Mannan Binding Lectin / MBL2 protein expression

Tissue specificity

Plasma protein produced mainly in the liver.

Mannan Binding Lectin / MBL2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    248.00
  • Mass (Da)
    26.00

Mannan Binding Lectin / MBL2 Antibody

There are 2 Mannan Binding Lectin / MBL2 antibodies which are validated in multiple tissues with various applications, including WB, IP, IHC-P. There are 1 Mannan Binding Lectin / MBL2 antibody for WB, 1 Mannan Binding Lectin / MBL2 antibody for IP, 1 Mannan Binding Lectin / MBL2 antibody for IHC-P. Among all these Mannan Binding Lectin / MBL2 antibodies, there are 2 anti-Mannan Binding Lectin / MBL2 rabbit polyclonal antibodies . All the Mannan Binding Lectin / MBL2 anbodies are produced in house and all are in stock. Mannan Binding Lectin / MBL2 antibody customerized service is available.

Mannan Binding Lectin / MBL2 Gene

MBL2 gene / cDNA is a protein-coding gene which located on 10q21.1. The MBL2 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, and frog.100 organisms have orthologs with human gene MBL2.