Mannan Binding Lectin / MBL2 Protein

Mannan Binding Lectin / MBL2 Protein Overview

Mannan Binding Lectin / MBL2 reagents

The MBL2 gene encodes a mannose-binding lectin (MBL), or protein (MBP), that is secreted by the liver as part of the acute-phase response and is involved in innate immune defense. The ligands for MBL are expressed by a wide variety of microorganisms, and binding of the protein leads to opsonization as well as activation of the complement system (Ohlenschlaeger et al., 2004).

Mannan Binding Lectin / MBL2 protein name

Recommended name
Mannose-binding protein C
Short name
MBP-C
Aliases
COLEC1
Alternative name
Collectin-1 MBP1 Mannan-binding protein Mannose-binding lectin

Mannan Binding Lectin / MBL2 Gene family protein

Mannan Binding Lectin / MBL2 Protein Sequence

Species Human Mannan Binding Lectin / MBL2 protein
Length 248
Mass (Da) 26144
Sequence Human Mannan Binding Lectin / MBL2 protein sequence
Species Mouse Mannan Binding Lectin / MBL2 protein
Length 244
Mass (Da) 25957
Sequence Mouse Mannan Binding Lectin / MBL2 protein sequence
Species Rat Mannan Binding Lectin / MBL2 protein
Length 244
Mass (Da) 26014
Sequence Rat Mannan Binding Lectin / MBL2 protein sequence

Mannan Binding Lectin / MBL2 Protein Molecular Weight & PI

Mannose-binding protein C precursor (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-248 Mannose-binding protein C.

Molecular weight (Da)

24020.92

Theoretical pI

5.40

Mannan Binding Lectin / MBL2 Protein Structure

HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL
Deposited
1994-09-21   Released:  1995-10-15
Deposition Author(s)
Sheriff, S.
Organism(s)
Homo sapiens
Expression System
Mus musculus
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.5000 Å
R-Value Work
0.199
1HUP From PDB

Human Mannan Binding Lectin / MBL2 protein Secondary structure

Mannan Binding Lectin / MBL2 Protein Interaction

Recombinant Mannan Binding Lectin / MBL2 Protein Feature

Mannan Binding Lectin / MBL2 Protein, Human, Recombinant

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant Mannan Binding Lectin / MBL2 protein citations

Title
Engineered microbe-targeting molecules and uses thereof
Year
2012
Author
DE Ingber, M Super, JC Way, MJ Cartwright…
Journal
US 20140227723 A1
Title
A generic pathogen capture technology for sepsis diagnosis
Year
2013
Author
Cooper, RM;
Journal
Thesis
Title
Characterization of the recognition of Candida species by mannose-binding lectin using surface plasmon resonance
Year
2013
Author
Damiens, S;Danze, PM;Drucbert, AS;Choteau, L;Jouault, T;Poulain, D;Sendid, B;
Journal
Analyst
Title
Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers
Year
2014
Author
JI Lai, AF Licht, AS Dugast, T Suscovich, I Choi…
Journal
Journal of Virology
Title
Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro
Year
2015
Author
Guo, J;Cao, Y;Qin, K;Zhao, X;Wang, D;Li, Z;Xin, L;Shu, Y;Zhou, J;
Journal
Biochem. Biophys. Res. Commun.
Title
Broad spectrum capture of clinical pathogens using engineered Fc-Mannose-Binding Lectin (FcMBL) enhanced by antibiotic treatment
Year
2018
Author
Seiler, B;Cartwright, M;Dinis, A;Duffy, S;Lombardo, P;Cartwright, D;Super, E;Lanzaro, J;Dugas, K;Super, M;Ingber, D;
Journal
bioRxiv
Title
Modified Clinical Monitoring Assessment Criteria for Multi-Organ Failure during Bacteremia and Sepsis Progression in a Pig Model
Year
2018
Author
Waterhouse, A;Leslie, DC;Bolgen, DE;Lightbown, S;Dimitrakakis, N;Cartwright, MJ;Seiler, B;Lightbown, K;Smith, K;Lombardo, P;Hicks-Berthet, JB;Jurek, S;Donovan, K;Super, M;Ingber, AP;
Journal
Advances in Critical Care Medicine

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