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LTK  Protein, Antibody, ELISA Kit, cDNA Clone

LTK 相关研究领域

LTK 相關信號通路

    LTK 概述&蛋白信息

    LTK 研究背景

    催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:10445845}.
    亞單位結構: Homodimer when bound to ligand (Probable). Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. {ECO:0000305}.
    亞細胞定位: Membrane; Single-pass type I membrane protein.
    組織特異性: Expressed in non-hematopoietic cell lines and T- and B-cell lines. {ECO:0000269|PubMed:2156206}.
    相關疾病 : DISEASE: Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B-cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system.
    相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    LTK 別稱

    TYK1, [homo-sapiens]

    LTK 相關文獻

    請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”