LIGHT cDNA Clone: Expression and Clone Vector / Plasmid

LIGHT cDNA / Gene Overview

TNFSF14 gene / cDNA is a protein-coding gene which located on 19p13.3. The TNFSF14 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.133 organisms have orthologs with human gene TNFSF14.

LIGHT cDNA / Gene Function

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

LIGHT cDNA / Gene Sequence

LOCUS
LOCUS NM_003807 4807 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens TNF superfamily member 14 (TNFSF14), transcript variant 1, mRNA.
ACCESSION
NM_003807
VERSION
NM_003807.4

This sequence information is just for reference only.

LIGHT Family & Reagents

LIGHT Gene family reagents (CD molecules)

Approved Symbol Reagent list
IL17RA
SELPLG
IL6R
CD99
CD86
SDC1
SIGLEC5
NCR1
CD68
MS4A1
Approved Symbol Reagent list
CLEC4A
CDH1
KLRC1
JAM2
KIR2DL5A
PSG1
TNFSF13B
NECTIN1
CD207
CDH5

LIGHT Gene family reagents (Tumor necrosis factor superfamily)

Approved Symbol Reagent list
CD40LG
FASLG
LTB
TNFSF10
TNFSF12
TNFSF13B
TNFSF18
TNFSF8
Approved Symbol Reagent list
CD70
LTA
TNF
TNFSF11
TNFSF13
TNFSF15
TNFSF4
TNFSF9

LIGHT cDNA / Gene Alias

  • CD258
  • HVEM-L
  • LIGHT
  • LTg

LIGHT cDNA / Gene Expression

Broad expression in liver (RPKM 1.5), appendix (RPKM 0.9) and 18 other tissues