LAG3 (Protein | Antibody | cDNA Clone | ELISA Kit)

All LAG3 reagents are produced in house and quality controlled, including 1 LAG3 Antibody, 43 LAG3 Gene, 10 LAG3 Lysate, 11 LAG3 Protein, 1 LAG3 qPCR. All LAG3 reagents are ready to use.

LAG3 Protein (11)

LAG3 Antibody (1)

LAG3 cDNA Clone (43)

NM_002286.5
NM_008479.2

In cloning vector

In expression vector

In lentiviral vector

NM_212513.2
XM_001108923.2

LAG3 qPCR Primer (1)

LAG3 Lysate (10)

LAG3 Background

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

LAG3 References

  • Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
  • Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
  • Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
  • Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
  • Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.