Immune Checkpoint Therapy-Achievements

Immune Checkpoint Therapy-Achievements Condition

Immune checkpoint therapy is striking in cancer immunotherapy, and numerous effors have been taken in Immune checkpoint therapy. Many achievements have been gained in immune checkpoint therapy based on the research on various immune checkpoint targets, especially the most popular ones: PD-1, PD-L1 and CTLA-4. Achievements of immune checkpoint therapy in cancer is detailed below.

Immune Checkpoint Therapy: Vital Information

Achievements of immune checkpoint therapy in cancer Details
Nivolumab A fully human immunoglobulin (Ig) G4 monoclonal antibody directed against immune checkpoint PD1/PDCD1/CD279.
PembrolizumabIn A humanized monoclonal immunoglobulin (Ig) G4 antibody directed against immune checkpoint PD1/PDCD1/CD279.
Pidilizumab A humanized, immunoglobulin (Ig) G1 monoclonal antibody directed against immune checkpoint PD1/PDCD1/CD279.
AMP-224 an anti-PD1/PDCD1/CD279 fusion protein, a recombinant B7-DC Fc-fusion protein composed of the extracellular domain of the PD1/PDCD1/CD279 ligand programmed cell death ligand 2 (PD-L2, B7-DC) and the Fc region of human immunoglobulin (Ig) G1.
BMS-936559 a fully human, anti– PD-L1/B7-H1/CD274, IgG4 monoclonal antibody.
MEDI4736 A Fc optimized monoclonal antibody directed against PD-L1/B7-H1/CD27.
MPDL3280A A human, Fc optimized, monoclonal antibody directed against the immune checkpoint PD-L1/B7-H1/CD274.
Avelumab A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the immune checkpoint PD-L1/B7-H1/CD274.
Tremelimumab A human immunoglobulin (Ig) G2 monoclonal antibody directed against the immune checkpoint CTLA-4/CD152.
MGA271 An engineered anti-B7-H3/CD276 mAb
Indoximod A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO).
INCB024360 An orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO)
Lirilumab A fully humanized monoclonal antibody against killer-cell immunoglobulin-like receptors (KIR)
BMS-986016 A monoclonal antibody directed against the immune checkpoint lymphocyte activation gene-3 (LAG-3).

Immune Checkpoint Therapy-Achievements: References

Howard (Jack) West, MD et al. Immune Checkpoint Inhibitors. JAMA Oncol. 2015;1(1):115.
Julie R. Brahmer et al. Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer. Cancer Immunol Res August 2013 1; 85.

Immune Checkpoint Therapy-Achievements: Relatives

Immune checkpoint therapy-combination Immune checkpoint therapy-advantages
Immune checkpoint therapy-adverse effects  
Immune Checkpoint
What is immune checkpoint?
Immune checkpoint targets
Immune checkpoint blockade: blocking antibodies
Immune checkpoint detection: antibodies
Immune checkpoint proteins
Immune checkpoint inhibitors
Immune checkpoint therapy
Immune checkpoint pathways
PD1 / PDCD1 / CD279 immune checkpoint
VISTA / B7-H5 / GI24 immune checkpoint