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Immune Checkpoint Protein

High Quality Immune Checkpoint Protein Assurance

  • • Endotoxin less than 1EU/μg by the LAL method
  • • Mutiple species: Human, Mouse, Canine, Rat etc.
  • • Validated bioactivity
  • • High purity (SDS-PAGE)

Figure 1. The activity assay of human PD1 protein
(His & Fc Tag, 10377-H03H)by binding to PD-L2.

Figure 2. The purity of human PD-L1 protein (10084-H08H)
was >98% as determined by SDS-PAGE.

Immune Checkpoint Protein by Targets

• Co-stimulatory Immune Checkpoint Targets

• Co-inhibitory Immune Checkpoint Targets

Immune Checkpoint Protein by species

Part of Featured Immune Checkpoint Protein

Catalogue Product name Purity Endotoxin
10039-H31H Human CD27 / TNFRSF7 Protein (Fc Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
10041-H03H Human CD137/4-1BB / TNFRSF9 Protein
(His & FcTag)
> 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
10042-H02H Human 2B4 / SLAMF / CD244 Protein (Fc Tag) > 97 % as determined by SDS-PAGE < 1.0 EU/μg protein
10109-H08H Human CD155 / PVR Protein (His Tag) > 97 % as determined by SDS-PAGE < 1.0 EU/μg protein
10344-H03H Human ICOS / AILIM / CD278 Protein (His & Fc Tag) > 94 % as determined by SDS-PAGE < 1.0 EU/μg protein
10567-M03H Mouse HVEM / TNFRSF14 Protein (His & Fc Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
10565-H08H Human CD226 / DNAM-1 Protein (His Tag) > 97 % as determined by SDS-PAGE < 1.0 EU/μg protein
10481-H08H Human TNFRSF4 / OX40 / CD134 Protein (His Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
10390-H08H Human TIM-3 / HAVCR2 Protein (His Tag) > 96 % as determined by SDS-PAGE < 1.0 EU/μg protein
10084-H02H Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
11159-H03H Human CTLA4 / CD152 Protein (His & Fc Tag) > 92 % as determined by SDS-PAGE < 1.0 EU/μg protein
10822-H08H Human CEACAM1 / CD66a Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
10797-H08H Human CD48 / SLAMF2 / BCM1 Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
80161-R07H Rat CD70 / CD27L / TNFSF7 Protein (His Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
10292-H08H Human B7-DC / PD-L2 / CD273 Protein (His Tag) > 98 % as determined by SDS-PAGE < 1.0 EU/μg protein

More Information about Immune Checkpoint

Background of Immune Checkpoint

Immune checkpoint therapies have attracted amounts of attention from scientists who are devoted to cancer treatment. What is immune checkpoint? It is a kind of co-stimulatory and inhibitory signal for regulating the antigen recognition of T cell receptor (TCR) in the process of immune responce. When immune system is attacking pathogens, these immune checkpoint molecules can protect the normal tissues from damage. The cancer cells cleverly escape from immune attack by dysregulating immune checkpoint related proteins. Immune checkpoint therapy relys on functioning immune system with agonists of co-stimulatory signals or antagonists of inhibitory signals. Over these years there are two immune checkpoint receptors that have been actively studied: cytotoxic T‑lymphocyte-associated antigen 4 (CTLA-4 / CD152) and programmed cell death protein 1 (PD1 / PDCD1 / CD279). The corresponding antibodies can inhibit the functioning of the receptors and enhance antitumour immunity. Furthermore, multiple additional immune checkpoints, representing promising targets for anti-cancer therapy are under active development, more therapies based on immune checkpoint for more cancers are on the way to the market.

You can visit the following website for all the immune checkpoint Proteins list. (http://www.sinobiological.com/immune-checkpoint-protein-ads-nff.html)

請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”