Immune Checkpoint Blockade: PD1 / PDCD1 / CD279 Blocking Antibodies

Immune checkpoint targets Antigen Species Host Ab type Catalog No.
PD1 / PDCD1 / CD279 Human
Human
Human
Mouse (humanized)
Mouse (humanized)
Mouse (chimeric)
MAb
MAb
MAb
10377-H944
10377-HF06
10377-mhT28

Immune Checkpoint Blockade Assay: PD1 / PDCD1 / CD279 Blocking Antibodies

PD1 / PDCD1 / CD279 Blocking Antibodies Immune Checkpoint Blockade Assay
PD1 / PDCD1 / CD279 Neutralizing Antibody (10377-H944) 1. In a functional ELISA, 1.5 µg/mL of this antibody will block 50% of the binding of 1 µg/mL of Recombinant Human PD1 (Catalog 10377-H02H) to immobilized Recombinant Human PD-L1 Fc Chimera (Catalog 10084-H02H) coated at 10 µg/mL (100 µL/well). At 3 μg/mL, this antibody will block >80% of the binding.
PD1 / PDCD1 / CD279 Neutralizing Antibody (10377-HF06) 2. In a functional ELISA, 0.2 µg/mL of this antibody will block 50% of the binding of 0.2 µg/mL of Recombinant Human PD1 (Catalog 10377-H02H) to immobilized Recombinant Human PD-L1 Fc Chimera (Catalog 10084-H02H) coated at 10 µg/mL (100 µL/well). And >90% blocking effect can be obtained with 0.6 μg/mL of antibody.
PD1 / PDCD1 / CD279 Blocking Antibody (10377-mhT28) 3. In a functional ELISA, 0.2-0.3 µg/mL of this antibody will block 50% of the binding of 0.2 µg/mL of Recombinant Human PD1 (Catalog 10377-H02H) to immobilized Recombinant Human PD-L1 Fc Chimera (Catalog 10084-H02H) coated at 10 µg/mL (100 µL/well). At 0.6 μg/mL, this antibody will block >90% of the binding.

Immune Checkpoint Blockade: PD1 / PDCD1 / CD279 Blocking Antibodies Relatives

Immune checkpoint blockade: PD-L1 / B7-H1 / CD274 blocking antibodies What is PD1 / PDCD1 / CD279 immune checkpoint
PD1 / PDCD1 / CD279 immune checkpoint pathway PD1 / PDCD1 / CD279 immune checkpoint antibodies
PD1 / PDCD1 / CD279 immune checkpoint proteins PD1/PDCD1/CD279 immune checkpoint inhibitors
PD1 / PDCD1 / CD279 immune checkpoint research  
Immune Checkpoint
What is immune checkpoint?
Immune checkpoint targets
Immune checkpoint blockade: blocking antibodies
Immune checkpoint detection: antibodies
Immune checkpoint proteins
Immune checkpoint inhibitors
Immune checkpoint therapy
Immune checkpoint pathways
PD1 / PDCD1 / CD279 immune checkpoint
VISTA / B7-H5 / GI24 immune checkpoint