IL-13: IL-13 Protein | IL-13 Antibody

IL-13 Gene family

IL-13 Background

Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.

Reference for IL-13

  • Junttila IS, et al. (2008) Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med. 205(11): 2595-608.
  • Shimamura T,et al. (2008) Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. J Immunol. 181(7): 4656-65.

IL-13 Protein

IL-13 protein function

Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). {ECO:0000250|UniProtKB:P20109, ECO:0000269|PubMed:8096327, ECO:0000269|PubMed:8097324}.

IL-13 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

IL-13 Antibody

There are 9 IL-13 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), ELISA(Cap). There are 7 IL-13 antibody for ELISA, 1 IL-13 antibody for ELISA(Det), 1 IL-13 antibody for ELISA(Cap). Among all these IL-13 antibodies, there are 4 anti-IL-13 mouse monoclonal antibodies , 1 anti-IL-13 rabbit monoclonal antibodies , 4 anti-IL-13 rabbit polyclonal antibodies . All the IL-13 anbodies are produced in house and all are in stock. IL-13 antibody customerized service is available.

IL-13 Gene

IL13 gene / cDNA is a protein-coding gene which located on 5q31.1. The IL13 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.114 organisms have orthologs with human gene IL13.