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IgG Fc Control Protein

Part of Featured lgG Fc Protein in Sino Biological Inc.

Catalogue Product name Purity Endotoxin
10702-HNAH Human IgG1-Fc Protein (103 Cys/Ser) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
10690-MNAH Mouse IgG1-Fc Protein (102 Cys/Ser) > 97 % as determined by SDS-PAGE < 1.0 EU/μg protein
13504-HNAH Human IgG2-Fc Protein (257 Ser/Ala) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
13505-HNAH Human IgG4-Fc Protein > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
51094-MNAH Mouse IgG2a-Fc Protein > 92 % as determined by SDS-PAGE < 1.0 EU/μg protein
51095-MNAH Mouse IgG2b-Fc Protein > 92 % as determined by SDS-PAGE < 1.0 EU/μg protein
51096-MNAH Mouse IgG3-Fc Protein > 92 % as determined by SDS-PAGE < 1.0 EU/μg protein
11047-TNAH Rabbit IgG-Fc Protein (185 Thr/Ala, Asn 284/Ser) > 92 % as determined by SDS-PAGE < 1.0 EU/μg protein
10702-HNAC Human IgG1 Fc Protein > 92 % as determined by SDS-PAGE < 1.0 EU/μg protein
13906-HNAH Human IgG3-Fc / IGHG3 Protein > 96 % as determined by SDS-PAGE < 1.0 EU/μg protein

lgG Fc Reagents Partial list by Molecules

Molecule Prorein Gene Antibody Molecule Prorein Gene Antibody
IgG             IgG2B            
IgG1               IgG2C                
IgG2                 IgG3            
IgG2a               IgG4                
Notes:The meaning of each icon described as followings. Human; Mouse; Rat; Rabbit;

lgG Fc Protein by Species

lg Related Molecules-Fc Receptor Proteins

• Fc Receptor binding IgG   • Fc Receptor binding IgA  
CD64 / FCGR1 Protein CD16b / FCGR3B Protein CD89 / FCAR Protein  
CD32a / FCGR2A Protein CD16-2 / FCGR4 Protein • Fc Receptor binding IgE
CD32b / FCGR2B Protein FCGRT & B2M Protein CD23 / FCER2 Protein MS4A2
CD16 / FCGR3 Protein FCGRT (cDNA available) FcERI / FCER1A Protein FCER1G
CD16a / FCGR3A Protein   • Fc Receptor-Like Receptor
• Fc Receptor binding IgA & IgM FCRL1 / FCRH1 Protein FCRL3
CD351 / FCAMR   FCRL4

Background of IgG Fc

There are five classes of immunoglobulins in humans, which are IgG, IgA, IgM, IgE and IgD. IgG can be further divided into four subclasses, IgG1, IgG2, IgG3 and IgG4 in humans, and IgG1, IgG2a, IgG2b and IgG3 in mice. IgG is abundant in serum with the longest half-life, which comprises 75% of immunoglobulins in circulation. IgG has a Y-shape structure with two identical light chains and two identical heavy polypeptide chains. The fragment crystallizable region (Fc region) represents the stem of the Y, which comprises two constant domains (CH2 and CH3) of the heavy chain. Fc region is responsible for effector functions through interactions with target molecules and receptors. Fc binding to Fc receptors on immune effector cells, such as natural killers and macrophages, elicits ADCC (antibody-dependent cell-mediated cytotoxicity), which leads to phagocytosis or lysis of the targeted cells. Fc region can also bind to complement components to mediate CDC (complement-dependent cytotoxicity). Mutations of Fc regions can improve or reduce their binding to molecules on effector cells as mentioned above.

請注意:所有產品都是“僅用於科研,而不能用於診斷或治療用途”