CD93 Matched ELISA Antibody Pair Set,Human

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CD93 Matched ELISA Antibody Pair Set,Human General Information

Product name
CD93 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human CD93
Assay range
31.25-2000 pg/mL
Materials provided
1. Capture Antibody 0.5 mg/mL of mouse anti-Human CD93/C1qR monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 12589-MM04)
2. Detection Antibody 0.2 mg/mL of mouse anti-Human CD93/C1qR monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.4 μg/mL in detection antibody dilution buffer before use. (Catalog: # 12589-MM02)
3. Standard Each vial contains 70(KW10AP1104-1) ng of recombinant Human CD93/C1qR. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 2000 pg/mL is recommended.
Product overview
This CD93 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human CD93 . It contains Human CD93 capture antibody, Human CD93 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human CD93 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

CD93 Matched ELISA Antibody Pair Set,Human Images

CD93 Matched ELISA Antibody Pair Set,Human: Alternative Names

C1qR Matched ELISA Antibody Pair Set, Human; C1qR(P) Matched ELISA Antibody Pair Set, Human; C1QR1 Matched ELISA Antibody Pair Set, Human; C1qRP Matched ELISA Antibody Pair Set, Human; CDw93 Matched ELISA Antibody Pair Set, Human; dJ737E23.1 Matched ELISA Antibody Pair Set, Human; ECSM3 Matched ELISA Antibody Pair Set, Human; MXRA4 Matched ELISA Antibody Pair Set, Human

CD93 Background Information

CD93 or C1q receptor 1 (C1qR) is an about 12 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes, neutrophils, endothelial cells, and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.
Full Name
CD93 molecule
References
  • Bohlson SS, et al. (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 175(2): 1239-47.
  • Norsworthy PJ, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol. 172(6): 3406-14.
  • Chevrier S, et al. (2009) CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A. 106(10): 3895-900.
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