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 TFRC/CD71  抗體

All TFRC Reagents

反應性: Human  
應用 : FCM  
11020-R040-P-25
11020-R040-P-100
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反應性: Human  
應用 : FCM  
11020-MM03-50
11020-MM03-200
11020-MM03-100
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反應性: Human  
應用 : IHC-P  IP  
11020-R016-50
11020-R016-100
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反應性: Human  
應用 : FCM  
11020-MM04-P-25
11020-MM04-P-100
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反應性: Human  
應用 : FCM  
11020-MM03-A-25
11020-MM03-A-100
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反應性: Human  
應用 : FCM  IF  ICC/IF  
11020-R040-50
11020-R040-100
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反應性: Human  
應用 : FCM  
11020-MM04-F-25
11020-MM04-F-100
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反應性: Human  
應用 : FCM  
11020-R040-C-25
11020-R040-C-100
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反應性: Human  
應用 : FCM  
11020-MM03-F-25
11020-MM03-F-100
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100 Tests 
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反應性: Human  
應用 : 
11020-MM03-C-25
11020-MM03-C-100
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反應性: Human  
應用 : FCM  
11020-MM03-P-25
11020-MM03-P-100
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反應性: Human  
應用 : 
11020-MM04-C-25
11020-MM04-C-100
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反應性: Human  
應用 : FCM  
11020-MM04-50
11020-MM04-200
11020-MM04-100
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200 µg 
100 µg 
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  • Slide 1
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反應性: Human  
應用 : FCM  
11020-MM04-A-25
11020-MM04-A-100
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100 Tests 
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反應性: Human  
應用 : ELISA  
11020-MM02-50
11020-MM02-200
11020-MM02-100
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    反應性: Human  
    應用 : ELISA  WB  IHC-P  IP  
    11020-RP02-50
    11020-RP02-100
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    反應性: Human  
    應用 : ELISA  WB  IP  
    11020-R001-50
    11020-R001-100
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    100 µg 
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    反應性: Human  
    應用 : ELISA  WB  
    11020-RP01-400
    11020-RP01-200
    11020-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反應性: Human  
    應用 : FCM  
    11020-R040-A-25
    11020-R040-A-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1
    • Slide 1
    反應性: Human  
    應用 : FCM  
    11020-R040-F-25
    11020-R040-F-100
    25 Test 
    100 Tests 
    Add to Cart
    • Slide 1

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    TFRC/CD71 相关研究领域

    TFRC/CD71 相關信號通路

      TFRC/CD71 概述&蛋白信息

      TFRC/CD71 研究背景

      基因概述: This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis.
      General information above from NCBI
      亞單位結構: Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:17287727}.
      亞細胞定位: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; Transferrin receptor protein 1, serum form: Secreted.
      誘導: Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.
      翻譯後修飾: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. {ECO:0000269|PubMed:1421756, ECO:0000269|PubMed:1421757, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:3582362}.; Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).; Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. {ECO:0000269|PubMed:3582362}.
      相似的序列: Belongs to the peptidase M28 family. M28B subfamily. {ECO:0000305}.; Contains 1 PA (protease associated) domain. {ECO:0000305}.
      General information above from UniProt

      Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

      TFRC/CD71 別稱

      TR,T9,TFR,CD71,TFR1,TRFR,P90, [homo-sapiens]
      TFR,Transferrin Receptor,CD71,TFR1,TFRC,TRFR, [human]
      Mtvr-1,TFR,Transferrin Receptor,Trfr,2610028K12Rik,AI195355,AI426448,AU015758,TR,CD71,E430033M20Rik,Mtvr1,p90,TFR1,Tfrc, [mouse]
      Tr,TFR,p90,CD71,TFR1,Trfr,Mtvr1,Mtvr-1,AI195355,AI426448,AU015758,2610028K12Rik,E430033M20Rik, [mus-musculus]

      TFRC/CD71 相關文獻

    • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
    • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
    • Tosoni D., et al., 2005, Cell 123:875-888.
    • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
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