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 IL-9  蛋白

All IL9 Reagents

描述: Active  
表達宿主: Baculovirus-Insect Cells  
11844-H08B-5
11844-H08B-20
11844-H08B-100
5 µg 
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100 µg 
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IL-9 相关研究领域

IL-9 相關蛋白、抗體、cDNA基因、ELISA試劑盒

IL-9 概述&蛋白信息

IL-9 研究背景

基因概述: The protein encoded by this IL9 gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. IL-9 stimulates cell proliferation and prevents apoptosis. IL-9 functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that IL-9 is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
General information above from NCBI
亞細胞定位: Secreted.
相似的序列: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
General information above from UniProt

Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells, synergizes with TGF-β1 to differentiate naïve CD4+ T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly, IL-9 enhances the suppressive functions of FoxP3+ CD4+ Treg cells in vitro, and absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight a role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses.

IL-9 別稱

HP40,IL-9,p40, [homo-sapiens]
IL-9,p40,HP40,IL9, [human]
Il-9,Il9,P40, [mouse]
Il-9,p40, [mus-musculus]

IL-9 相關文獻

  • Elyaman W, et al. (2009) IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 106(31): 12885-90.
  • Dong Q, et al. (1999) IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur J Immunol. 29(7): 2130-9.
  • Kimura Y, et al. (1995) Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Int Immunol. 7(1): 115-20.
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