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 IL-28B/IFN-lambda-3  蛋白

All IL-28B Reagents

描述: Active  
表達宿主: Human Cells  
11890-H08H-50
11890-H08H-5
11890-H08H-20
50 µg 
5 µg 
20 µg 
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表達宿主: Yeast  
11890-H08Y-20
11890-H08Y-100
20 µg 
100 µg 
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IL-28B/IFN-lambda-3 相关研究领域

IL-28B/IFN-lambda-3 相關信號通路

    IL-28B/IFN-lambda-3 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    IL-28B/IFN-lambda-3 概述&蛋白信息

    IL-28B/IFN-lambda-3 研究背景

    基因概述: This IL28B gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
    General information above from NCBI
    亞細胞定位: Secreted {ECO:0000269|PubMed:12483210}.
    誘導: By viral infections or double-stranded RNA. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.
    相似的序列: Belongs to the lambda interferon family. {ECO:0000305}.
    General information above from UniProt

    Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNλ) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8+ T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.

    IL-28B/IFN-lambda-3 別稱

    IL-28B/IFN-lambda-3 相關文獻

  • Ge D, et al.. (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 461(7262): 399-401.
  • Morrow MP, et al.. (2009) Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity. Blood. 113(23): 5868-77.
  • Sheppard P, et al.. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol. 4(1): 63-8.
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