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 IL16  蛋白

All IL16 Reagents

IL16
描述: Active  
表達宿主: E. coli  
10944-H07E-50
10944-H07E-5
10944-H07E-20
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IL16 相关研究领域

IL16 相關信號通路

    IL16 相關蛋白、抗體、cDNA基因、ELISA試劑盒

    IL16 相關蛋白、抗體、cDNA基因、ELISA試劑盒

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    IL16 概述&蛋白信息

    IL16 研究背景

    基因概述: The protein encoded by IL-16 gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
    General information above from NCBI
    亞單位結構: Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax. {ECO:0000250, ECO:0000269|PubMed:12620798, ECO:0000269|PubMed:12923170, ECO:0000269|PubMed:18097041, ECO:0000269|PubMed:7910967, ECO:0000305}.
    亞細胞定位: Interleukin-16: Secreted.; Isoform 1: Cytoplasm {ECO:0000250}.; Isoform 3: Cytoplasm. Nucleus.
    組織特異性: Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.
    誘導: Isoform 3 is down-regulated in T-cells after TCR activation. {ECO:0000269|PubMed:11276202}.
    翻譯後修飾: Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16. {ECO:0000269|PubMed:9422780}.
    相似的序列: Contains 4 PDZ (DHR) domains. {ECO:0000255|PROSITE-ProRule:PRU00143}.
    General information above from UniProt

    IL16 別稱

    LCF,NIL16,PRIL16,prIL-16, [homo-sapiens]
    FLJ16806,FLJ42735,FLJ44234,IL16,IL-16,LCF,NIL16,PRIL16,prIL-16, [human]
    Il16,KIAA4048,mKIAA4048,IL-16, [mouse]
    mKIAA4048, [mus-musculus]

    IL16 相關文獻

  • Maciaszek JW, et al. (1997) IL-16 represses HIV-1 promoter activity. J Immunol. 158(1): 5-8.
  • Zhou P, et al. (1997) Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med. 3(6): 659-64.
  • Theodore AC, et al. (1996) CD4 ligand IL-16 inhibits the mixed lymphocyte reaction. J Immunol. 157(5): 1958-64.
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