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 HSP70/HSPA1A  抗體

All HSP70 Reagents

反應性: Human  
應用 : 
11660-MM12-50
11660-MM12-200
11660-MM12-100
50 µg 
200 µg 
100 µg 
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反應性: Human  
應用 : 
11660-MM15-50
11660-MM15-200
11660-MM15-100
50 µg 
200 µg 
100 µg 
Add to Cart
    反應性: Human  
    應用 : ELISA  
    11660-RP01-400
    11660-RP01-200
    11660-RP01-100
    400 µg 
    200 µg 
    100 µg 
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      反應性: Human  
      應用 : FCM  
      11660-R001-F-25
      11660-R001-F-100
      25 Test 
      100 Tests 
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      反應性: Human  
      應用 : ELISA  WB  IHC-P  FCM  IF  IP  ICC/IF  
      11660-R001-50
      11660-R001-100
      50 µg 
      100 µg 
      Add to Cart
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      反應性: Human  
      應用 : ELISA  WB  IP  
      11660-T52-50
      11660-T52-200
      11660-T52-100
      50 µg 
      200 µg 
      100 µg 
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      HSP70/HSPA1A 相关研究领域

      HSP70/HSPA1A 相關信號通路

      HSP70/HSPA1A 相關蛋白、抗體、cDNA基因、ELISA試劑盒

      HSP70/HSPA1A 概述&蛋白信息

      HSP70/HSPA1A 研究背景

      基因概述: Heat shock 70 kDa protein 1 is a protein that in humans is encoded by the HSPA1A gene. This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this HSP72 protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. HSP72 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSPA1A gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
      General information above from NCBI
      亞單位結構: Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with TRIM5 (via B30.2/SPRY domain). Interacts with METTL21A. Interacts with PARK2. Interacts with FOXP3. {ECO:0000269|PubMed:10216320, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:15383005, ECO:0000269|PubMed:15963462, ECO:0000269|PubMed:17233114, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:18620420, ECO:0000269|PubMed:20053985, ECO:0000269|PubMed:20072699, ECO:0000269|PubMed:20179333, ECO:0000269|PubMed:20223214, ECO:0000269|PubMed:21081504, ECO:0000269|PubMed:23921388, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24270810}.
      亞細胞定位: Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
      組織特異性: HSPA1B is testis-specific.
      誘導: By heat shock.
      相似的序列: Belongs to the heat shock protein 70 family. {ECO:0000305}.
      General information above from UniProt

      HSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upon temperature shock or other stress stimuli, HSP are synthesized intracellularly, which may protect cells from protein denaturation or from death. Extracellularly, HSP can serve a cytokine function to initiate both innate and adaptive immunity through activation of APC. HSP serves also a chaperone function and facilitates presentation of antigen peptide to T cells. Molecular chaperones of the Hsp70 family have diverse functions in cells. They assist the folding of newly synthesized and stress-denatured proteins, as well as the import of proteins into organelles, and the dissociation of aggregated proteins. The well-conserved Hsp70 chaperones are ATP dependent: binding and hydrolysis of ATP regulates their interactions with unfolded polypeptide substrates, and ATPase cycling is necessary for their function. All cellular functions of Hsp70 chaperones use the same mechanism of ATP-driven polypeptide binding and release. 

      HSP70/HSPA1A 別稱

      HSP72,HSPA1,HSP70I,HSP70-1,HSP70-1A,HEL-S-103, [homo-sapiens]
      DAQB-147D11.1,FLJ54303,FLJ54370,FLJ54392,FLJ54408,FLJ75127, [human]
      Hspa1b,Hsp70-1,HSP72,Hspa1, [mouse]
      Hsp72,hsp68,Hsp70-3,Hsp70.3,hsp70A1, [mus-musculus]

      HSP70/HSPA1A 相關文獻

    • Heck TG, et al. (2011) HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain Cell Biochem Funct. 29 (3): 215-26.
    • Chen T, et al. (2010) Stress for maintaining memory: HSP70 as a mobile messenger for innate and adaptive immunity. Eur J Immunol. 40 (6): 1541-4.
    • Young JC. (2010) Mechanisms of the Hsp70 chaperone system. Biochem Cell Biol. 88 (2): 291-300.
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